Cannabinoid dosages and duration of treatment depend mainly on the will result in more drawn-out effects that also take longer to kick in than some of the other options. . with using CBD in high doses or for extended periods of time, including: As if you didn't have enough factors to consider when deciding your ideal. Whether you're a first-time user or an experienced user, your proper CBD dosage is to take 1–6MG of CBD for every 10 pounds of body When in doubt, consult your physician, especially if you have an Since the methods we mentioned so far have only been semi-accurate, you're probably wondering. For a more in-depth look at how it feels to take CBD, you can read this article This is an important question as it allows you to devise an appropriate dosing schedule, After consuming about mg per day during this time period, the near high enough to cause you to test positive in a drug screening.
of take 4. of correct a you CBD over enough Did the dosage time. period long
Remember, there has never been a death from marijuana or CBD use. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Tammy M October 9, I have cervical dystonia with head tremors. Been receiving Botox injections with really no good results.
I want to try CBD oil to calm tremor down but unsure of which one or how much to take. Can you help me? Laura Richards October 8, After fighting the effects of thyroid cancerfor 12 years I wanted to die. Now, please understand that these were thoughts with no actions, I was just miserable in pain.
After 1 week on the CBD oil, 5 drops under the toungue 2x per day I am a different woman. I now have hope. Cindy September 6, I suffer fr migraines.
Currently having Botox injections every three months for the last three years. This has helped went fr 24 to 30 migraines a month to 6 to 8 , now I'm back up to 14 to 20 a month. My doctor thought CBD oil might help. I have also started having anxiety attacks for a year now. I'm really confused with the dosages. Any thoughts would b helpful. Pat keener September 3, I'm a type 2 diabetic, have degenerative dics, osteoarthritis, skin alergies,finger and feet neuropathy.
What dosage and product is good for these issues. Ebony November 3, I have the same thing. I was told cbd oil mg. Larry August 19, I have crohns dibeates 2 stage kidney failure I take mg of chemicals a day when I get a flair l might lose a lot of blood I've had fistula surgery once darn mean killed me 2 more just gut surgerys little bit of gut removed I tease my gut doctor he schoold just put in a zipper any way I'm looking for something natural to try for pain also where I live if you get caught automatic life so the delima begins how much would any one suggest starting out with thanks for your time also compared to most of the folks mine seems like a minor problem on this site but I would appreciate some advice I hope all you folks have good lives and remember god always loves you even though sometimes you think he may have forgotten you.
Heidi April 9, Hello I have crohns disease severe also. I also have ulcerative colitis I have had part of my upper and lower bowel removed. I am now trying cbd oil the euphoria one I just started taking it so still learning it seems to be helping a lot I take it 4 times a day about a dropper full. If you have any other insight it would be much appreciated Heidi.
Pat Irwin August 13, What product should I try and at what dose? I need a high dose. Casey June 3, Hi, I was also diagnosed with MS has anyone given you the correct dosage yet? Glenda Bishop August 10, I have severe neuropathy in both feet and legs.
I just got the CBD oil and I am interested in learning if anyone out there has had any success with this. I know each case and pain levels are different. Just would like to see some positive remarks from people who suffer with it.
I am not looking for a cure just need an update on someone who took and it helped. I already know there is no cure. I need help with the pain. I had a client using CBD from whole hemp for neuropathy with great success!
The most important thing is taking it apart from other medications esp for heart, and giving yourself enough of a dose. If I were you, I would just go slow for the first few days then go up. Meyers March 21, I also have severe neuropathy, pain in both knees, hips and lower back.
I just bought a bottle of Hemp Oil and an unmarked dropper. I need to know how many drops do I start with. Thank you for any help. Diane March 24, I suffer from severe neuropathy in both feet. I bought some CBD oil today and started with 3 drops at 2 pm and 3 drops at 9: I am praying it works. Miss Lyn Nichols July 19, Hi Diane, how did you go on with the CBD oil please. If it worked how long before you saw any results.
I'm scared of flaring everything. Nerve damage across buttocks from a surgeon who found the nerve stuck to the bulge during a laminectomy operation and prised it off.
I haven't sat for 5 years and getting worse. A muscle in my buttock is now throbbing constantly and causing pain to the muscle above. I've only started taking it today but the muscle pain is still as painful.
Does it take a while for it to work. Only started on low dose to see what happens. Karen August 13, I have idiopathic peripheral neuropathy I picked up some CBD oil yesterday morning. I am prescribed to take 75 mg of lyrica 3x per day. I took one yesterday morning and have only used the CBD oil since. I bought the Koi brand, flavored, MG. I used a full dropper yesterday late morning and a full dropper yesterday late afternoon.
I used it once today one full dropper and I am amazingly pain free. Lauren June 5, I have severe neuropathy from mid torso down. I started reducing the gabipitin every two weeks because of the success with CBD. This is my second attempt to get away from the synthetic drugs with CBD oil. The first time was not taking enough, now I take three dropper full everyday.
Hi Lauren I've just started today with mg cbd oil. I'm starting low to see what happens. I've nerve damage across buttocks from a laminectomy. I've not been able to sit for 5 years. I've recently started with a muscle spasm in my left buttock and the muscle above is painful. It is only the first day, also tried a cbd night time tea as well.
Do change in muscle pain so tight on my left hand side. How long before felt it starting to work please. I'm trying not to expect changes straightaway. I also take mg gabapentin and 30mg amitriptyline and I hate both of them - they both can cause muscle tightness affecting the nerve.
Jacki August 12, Acupuncture helped my painful feet. They are or never will be perfect but so much better. Just bought some cbd drops trying tobfigure out how much to take. Denise August 6, I also have a daughter on the Autism spectrum with anxiety. She weighs about - Does anyone else give CBD to someone with autism, and if so, at what dose?
Brenda March 23, I have a friend that gives it to her son whom is severely autistic. It calms him down and helps him to sleep well. Suzanne Arthurs July 22, Keum Chough July 20, Does it mean to say that no more treatment needed and it would cure it?? Indeed mg a day is enormous amount not to mention the cost to be realistic as a treatment.
Your response is appreciated. Eddy December 22, Pardon me, I looked at a clinical trial and they are testing mg twice a day with addition to regular medication one would take for schizophrenia. My dad has severe advanced stage Dementia. Will CBD oil help him at this point? He is now refusing to eat any solid food, but will accept most drinks. In addition, he has lost a great deal of weight even though they're giving him Mega Shakes containing a full meals worth of proteins, etc.
He gets at least 4 of these a day.. Is his Dementia too far gone for CBD oils to help him? Kent Autrey July 8, Emily April 1, Kent, My mother has suffered from severe migraines since she was a child. Six weeks ago, she received the hemp oil tincture I do not know what dosage. She does not take it daily. She rubs a drop or two on her temples at the start of a migraine.
The drops worked more effectively for her than her medication did, and now that is all she uses. Mike June 27, Morher-inlaw 78 just diagnosed with lymph node breast cancer. Due to her age wondered of CBD would be useful and her situation.
Chemotherapy would just kill her I believe. Just looking for Alternatives any information would be great thank you. Mike, what kind of breast cancer invasive ductal, I presume? How many of her lymph nodes were positive?
How big was the primary tumor? That type of breast cancer mentioned above, which I had as Stage IA, is treated in postmenopausal women with anti-estrogen drugs called aromatase inhibitors aka AIs: CBD oil is effective for this joint pain it is not, I repeat, NOT a substitute for chemo, radiation or these anti-estrogen drugs.
If she lives in a state where medical marijuana is legal, there are doctors who sub-specialize in certifying applications for a medical marijuana card, and in the interim before the card is issued can advise as to the appropriate dose of CBD oil legal and over-the-counter in all 50 states. Eve Klatt June 12, I have lower back pain with some arthritis and arthritis in my hands.
It really does work. I have the drops and ointment. Because of the back pain I never would have been able to go on a hike with my family. We had a lot of fun. And "No Pain", all day.
I'm also Type 2 diabetic. Anxious to see what my A1C is next month. Melanie April 20, Angela Torrance May 1, Hi Candy I also have lower back pain and arthritis in fingers can you tell me what type of oil you take and the dose please I am anxious to see if it will do me any good although Im not sure I can get it in Scotland!? Rosita June 9, Hi, I had ovarian cancer stage 2 and went to do chemotherapy for 16 times in It came back last year but I did not do chemotherapy or radiation therapy as suggested by the doctor.
I am taking hormone therapy at the moment. Can anyone give some idea?. Thank you very much. Lewi May 23, Hi, My dad has severe Neuropathy in both his feet and Parkinsons disease. There are several kinds of CBD oils out there, what kind would be the best to use brand and what might be the dosage.
Thank you very much,Gordon. Customer Care May 25, Unfortunately due to strict FDA regulations I am unable to make claims on our products based on your specific needs, I can however say that CBD is a natural anti-inflammatory and could assist. I can also share our top selling products in each category. Please view the links below: Doug May 14, What is the right product strength for a 75 yr old female with stage IV lung cancer metastic to her bones.
Both for pain and hopefully to slow down and kill cancer cells? Please help me, I am her husband and desperate. Customer Care May 29, Thanks for your interest in our products. Unfortunately due to strict FDA regulations I am unable to make claims on our products based on your specific needs, I can however share our top selling products in each category. There are so many uses for CBD and it's great to see that you have included the fact that many conditions such as schizophrenia require larger doses of up to 1,mg per dose day JT April 4, Victoria Hebner April 4, The dosage recommendations come from the manufacturers themselves.
I hope this helps. I just started taking CBD oil , I am on my 2nd Hip replacement surgery due to device failures looking at a 3rd surgery. Has you can imagine the pain, stress and anxiety levels are off the charts.
Especially at an otherwise healthy 54 yr women. So i understand from reading posts its best to take it under the tongue. I am taking ml a day. I can tell some difference,is your recommended dosage. I am using for pain , stress and sleep. I appreciate your feedback. Dawn Theilgaard March 23, I was wondering if anyone has has used cbd oil to aid with skitzophrenia. I have read that it helps one to focus and silences the voices one may hear.
I am trying to help my son as he has been on many meds and none have really worked. I have asked his dr about this treatment and he did tell me I could try it. Sandra March 17, My daughter is on the spectrum for Autism and has anxiety. She is 12 years old and weighs about lbs. I'm wondering what dosage to give her for her anxiety? Madelen Poston March 13, My husband has stage 4 liver cancer.
He has no appetite, and can't sleep. What strength and how much should he take for relief? Victoria Hebner March 23, Unfortunately, due to strict FDA laws, I am not legally able to say that CBD will help with your husbands specific condition, however I can direct you to some literature to help you better understand what CBD may offer. I have attached links below. As far as strength and dosage goes, tinctures and concentrates are absorbed the fastest since it goes directly into your blood stream; the dosage on these can be measured and controlled.
Capsules take a little longer to enter your body since it goes through your digestive tract, these are also measured and controlled. I would recommend reading through our page on dosing as well to get a better understanding. Nik Oakley June 14, Customer Care June 15, Douglas Murphy February 2, Have arthritis severe pain in hands started CBD last week almost pain free and makes me feel better.
Debbie ganote December 21, LE November 26, I wanted to tell people here that CBD has been very effective for my anxiety, and helps with insomnia.
For me, it was a cumulative effect, after a week of one dropper of oil, I can sleep very well at night. I feel like I am not polluting my body with commercial pharmaceuticals. I wish everyone here the best, and hope it works for you as well as it has for me.
Sfelts February 25, I have it really bad on top of Sciatica. Jerry September 18, I have benign essential tremor, primarily of my hands. I'm 75 years old. I've heard of CBD oil and wonder if it would be beneficial for me. If so, what would be the suggested amount and dosage?
Raquel Torres June 13, I want to give my mom CBD oil she is 97 and not sure how much to give her, she has dementia and has lost her ability to speak, and often cries when I leave the house she is in, my son sent me some oil that is labeled as anxiety relief tincture LadyLady November 17, Did you figure out how much to give her? Bronson August 14, Use coconut oil or MCT oil to treat dementia. The spice turmeric could help too.
My mom is late stage dementia. Gives only tine bit of help, and is not something that reverses dementia. Maybe in someone who can score better than a 14 on the mme it could be of help.
But cannabinoid is a different story. Cannabinoids produce better results in less time. Can't say yet that they will reverse anything though. Carolyn September 20, Ted spring May 26, I have severe arthist in my lower spin end hips. Pain all the time. How much cbd should I start vapeing? Rita Grier October 29, Barb March 31, I am new to using cbd oil.
I take 1 tablespoon daily and have had great result from doing this. My issues are arthritis, bulging disc and periferal neuropathy I look forward to my days now with the relief I have achieved with Cbd.
Woody May 7, Woody, i also suffer from arthritis and neuropathy in my feet so far. How has cbd oil helped you. I have severe neuropathy in my feet and legs. I just bought the CBD oil and need to know how many drops to take and has it helped you. Jeannie December 20, I just started vaping CBD for life long anxiety. I will tell you it is a miracle thing. Hardly think of my meds. I know I have to get off of Klonopin slowly, but I don't need it. Zac February 17, The time of onset and duration of effect vary depending on the method of administration.
CBD -rich cannabis oil products can be taken sublingually, orally as edibles or gel caps , or applied topically. Concentrated cannabis oil extracts can also be heated and inhaled with a vape pen. Inhalation is good for treating acute symptoms that require immediate attention. The effects can be felt within a minute or two and typically last for a couple of hours. Interest in CBD is huge and growing, particularly among new medical marijuana patients who don't want to get high.
But many health professionals have little experience with cannabis therapeutics and have a hard time guiding people in this area.
An effective dosage may range from as little as a few milligrams of CBD -enriched cannabis oil to a gram or more. Take a few small doses over the course of the day rather than one big dose. Use the same dose and ratio for several days. Observe the effects and if necessary adjust the ratio or amount.
Cannabis compounds have biphasic properties, which means that low and high doses of the same substance can produce opposite effects. Small doses of cannabis tend to stimulate; large doses sedate. Too much THC , while not lethal, can amplify anxiety and mood disorders. CBD has no known adverse side effects, but an excessive amount of CBD could be less effective therapeutically than a moderate dose.
Look for products with clear labels showing the quantity and ratio of CBD and THC per dose, a manufacturing date, and a batch number for quality control. Select products with quality ingredients: No corn syrup, transfats, GMO s, artificial additives, thinning agents or preservatives.
CBD did not lead to adverse effects. In addition, psychomotor function and psychological functions were not disturbed. Interestingly, the CYP2C19 inhibitor omeprazole, used to treat gastroesophageal reflux, could not significantly affect the pharmacokinetics of CBD. Unfortunately, it was not mentioned whether this effect was mediated via the cytochrome P complex. Another aspect, which has not been thoroughly looked at, to our knowledge, is that several cytochrome isozymes are not only expressed in the liver but also in the brain.
It might be interesting to research organ-specific differences in the level of CBD inhibition of various isozymes. Apart from altering the bioavailability in the overall plasma of the patient, this interaction might alter therapeutic outcomes on another level. Generally, more human studies, which monitor CBD-drug interactions, are needed. In a double-blind, placebo-controlled crossover study, CBD was coadministered with intravenous fentanyl to a total of 17 subjects.
This was followed by a single 0. This extensive tool tests, for example, 78 adverse effects divided into 23 categories corresponding to organ systems or body parts. No respiratory depression or cardiovascular complications were recorded during any test session.
The results of the evaluation of pharmacokinetics, to see if interaction between the drugs occurred, were as follows. No effect was evident for urinary CBD and metabolite excretion except at the higher fentanyl dose, in which CBD clearance was reduced. Importantly, fentanyl coadministration did not produce respiratory depression or cardiovascular complications during the test sessions and CBD did not potentiate fentanyl's effects. No correlation was found between CBD dose and plasma cortisol levels.
CBD did not worsen the adverse effects e. Coadministration was safe and well tolerated, paving the way to use CBD as a potential treatment for opioid addiction. A Dutch study compared subjective adverse effects of three different strains of medicinal cannabis, distributed via pharmacies, using VAS. The 12 adjectives used for this study were as follows: This strain showed significantly lower levels of anxiety and dejection.
Moreover, appetite increased less in the high CBD strain. The review by Bergamaschi et al. This holds especially true for the extrapyramidal motor side effects elicited by classical antipsychotic medication. Order of drug administration was pseudorandomized across subjects, so that an equal number of subjects received any of the drugs during the first, second, or third session in a double-blind, repeated-measures, within-subject design.
This effect was caused by opposite neural activation of relevant brain areas. In addition, no effects on peripheral cardiovascular measures such as heart rate and blood pressure were measured. A randomized, double-blind, crossover, placebo-controlled trial was conducted in 16 healthy nonanxious subjects using a within-subject design. The doses were selected to only evoke neurocognitive effects without causing severe toxic, physical, or psychiatric reactions.
The physiological parameters, heart rate and blood pressure, were also monitored and no significant difference between the placebo and the CBD group was observed. A case study describes a patient treated for cannabis withdrawal according to the following CBD regimen: Hepatic enzymes were also measured daily, but no effect was reported.
Naturalistic studies with smokers inhaling cannabis with varying amounts of CBD showed that the CBD levels were not altering psychomimetic symptoms. CBD might work to alleviate disorders of addiction, by altering the attentive salience of drug cues.
The study did not further measure side effects. CBD can also reduce heroin-seeking behaviors e. This was shown in the preclinical data mentioned earlier and was also replicated in a small double-blind pilot study with individuals addicted to opioids, who have been abstinent for 7 days. One hour after the video session, subjective craving was already reduced after a single CBD administration.
The effect persisted for 7 days after the last CBD treatment. Interestingly, anxiety measures were also reduced after treatment, whereas no adverse effects were described.
A pilot study with 24 subjects was conducted in a randomized, double-blind, placebo-controlled design to evaluate the impact of the ad hoc use of CBD in smokers, who wished to stop smoking. Pre- and post-testing for mood and craving of the participants was executed. Craving was assessed using the Tiffany Craving Questionnaire On day 1 and 7, exhaled CO was measured to test smoking status. Sedation, depression, and anxiety were evaluated with the MRS.
At day 7, the anxiety levels for placebo and CBD group did not differ. CBD did not increase depression in contrast to the selective CB1 antagonist rimonabant. CBD might weaken the attentional bias to smoking cues or could have disrupted reconsolidation, thereby destabilizing drug-related memories. To the best of our knowledge, no acute studies were performed that solely concentrated on CBD glycemic effects. Moreover, the only acute study that also measured CBD effect on appetite was the study we described above, comparing different cannabis strains.
Growth hormone and prolactin levels were unchanged. Compared to the healthy individuals, the cortisol levels increased less after TSST in the 32 at-risk individuals.
The CBD group showed less reduced cortisol levels but differences were not significant. Truly chronic studies with CBD are still scarce. Nonetheless, we also included these studies with repeated CBD treatment, because we think that compared to a one-time dose of CBD, repeated CBD regimens add value and knowledge to the field and therefore should be mentioned here.
These results are supported by another study described in the review by Grotenhermen et al. CBD was administered on average with three other drugs, including clobazam The coadministration led to an alteration of blood levels of several antiepileptic drugs.
In the case of clobazam this led to sedation, and its levels were subsequently lowered in the course of the study. A first pilot study in healthy volunteers in by Mincis et al.
Clinical chronic lasting longer than a couple of weeks studies in humans are crucial here but were mostly still lacking at the time of writing this review. They hopefully will shed light on the inconsistencies observerd in animal studies. Chronic studies in humans may, for instance, help to test whether, for example, an anxiolytic effect always prevails after chronic CBD treatment or whether this was an artifact of using different animal models of anxiety or depression. In a 4-week open trial, CBD was tested on Parkinson's patients with psychotic symptoms.
This led to a reduction of their psychotic symptoms. Moreover, no serious side effects or cognitive and motor symptoms were reported. No adverse effects were observed and her symptoms improved. The same positive outcome was registered in another study described by Bergamaschi et al.
The respective treatment was maintained for three additional weeks. This was the case for three patients in the CBD group and five patients in the amisulpride group. CBD treatment was accompanied by a substantial increase in serum anandamide levels, which was significantly associated with clinical improvement, suggesting inhibition of anandamide deactivation via reduced FAAH activity.
In addition, the FAAH substrates palmitoylethanolamide and linoleoyl-ethanolamide both lipid mediators were also elevated in the CBD group. CBD showed less serum prolactin increase predictor of galactorrhoea and sexual dysfunction , fewer extrapyramidal symptoms measured with the Extrapyramidal Symptom Scale, and less weight gain.
Moreover, electrocardiograms as well as routine blood parameters were other parameters whose effects were measured but not reported in the study. CBD better safety profile might improve acute compliance and long-term treatment adherence. A press release by GW Pharmaceuticals of September 15th, , described 88 patients with treatment-resistant schizophrenic psychosis, treated either with CBD in addition to their regular medication or placebo.
Important clinical parameters improved in the CBD group and the number of mild side effects was comparable to the placebo group. Moreover, neurological and physiological examinations were performed, which neither showed signs of CBD toxicity nor severe side effects.
The study also illustrated that CBD was well tolerated. CBD in addition to their regular epilepsy medication. Another clinical study lasting at least 3 months with children and young adults with various forms of epilepsy, who were treated with the CBD drug Epidiolex, was presented at the American Academy for Neurology in In a few cases, severe side effects occurred, but it is not clear, if these were caused by Epidiolex. The largest CBD study conducted thus far was an open-label study with Epidiolex in patients mainly children, the average age of the participants was 11 suffering from severe epilepsy, who could not be treated sufficiently with standard medication.
Ten percent of the patients reported side effects tiredness, diarrhea, and exhaustion. After extensive literature study of the available trials performed until September , CBD side effects were generally mild and infrequent. The only exception seems to be a multicenter open-label study with a total of patients aged 1—30 years, with treatment-resistant epilepsy.
This led to a reduction in seizure frequency. It is therefore difficult to put the side effect frequency into perspective. Attributing the side effects to CBD is also not straightforward in severely sick patients. Thus, it is not possible to draw reliable conclusions on the causation of the observed side effects in this study.
This rating instrument comprised the following factors: This assessment instrument analyzes adverse medication effects, including psychic, neurologic, autonomic, and other manifestations.
Using various safety outcome variables, clinical tests, and the cannabis side effect inventory, it was shown that there were no differences between the placebo group and the CBD group in the observed side effects. The occurrence of various degrees of GVHD was compared with historical data from patients, who had only received the standard treatment.
This resulted in lower resistin levels compared to baseline. The hormone resistin is associated with obesity and insulin resistance. Compared to baseline, glucose-dependent insulinotropic peptide levels were elevated after CBD treatment.
This incretin hormone is produced in the proximal duodenum by K cells and has insulinotropic and pancreatic b cell preserving effects. CBD was well tolerated in the patients. However, with the comparatively low CBD concentrations used in this phasetrial, no overall improvement of glycemic control was observed.
When weight and appetite were measured as part of a measurement battery for side effects, results were inconclusive. For instance, the study mentioned above, where 23 children with Dravet syndrome were treated, increases as well as decreases in appetite and weight were observed as side effects. However, in the safety analysis group, consisting of subjects, 10 showed decreased weight and 12 had gained weight.
Both these factors were not controlled for in the reviewed studies. This review could substantiate and expand the findings of Bergamaschi et al. First, more studies researching CBD side effects after real chronic administration need to be conducted.
Many so-called chronic administration studies, cited here were only a couple of weeks long. Second, many trials were conducted with a small number of individuals only. To perform a throrough general safety evaluation, more individuals have to be recruited into future clinical trials. Third, several aspects of a toxicological evaluation of a compound such as genotoxicity studies and research evaluating CBD effect on hormones are still scarce.
Especially, chronic studies on CBD effect on, for example, genotoxicity and the immune system are still missing. Last, studies that evaluate whether CBD-drug interactions occur in clinical trials have to be performed. In conclusion, CBD safety profile is already established in a plethora of ways.
However, some knowledge gaps detailed above should be closed by additional clinical trials to have a completely well-tested pharmaceutical compound. The study was commissioned by the European Industrial Hemp Association. EIHA paid nova-Institute for the review. Iffland K, Grotenhermen F An update on safety and side effects of cannabidiol: National Center for Biotechnology Information , U.
Cannabis health products are everywhere – but do they live up to the hype?
Cannabidiol, or CBD, is now available in the UK in everything from skin creams to beers. While THC can make you feel edgy, CBD does the opposite. amounts of CBD that might not have large enough concentrations to While it looks unlikely that the recommended doses of these products will do any. One editor explains how she took CBD oil every day for a week to help her anxiety. Unlike THC, the other crucial compound in hemp and marijuana plants , CBD does not it actually eases anxiety and makes you less likely to freak out. Considering it takes time, consistency, and the right dosage to. Cannabidiol or CBD is a component of the cannabis plant that may have is one that provides an optimal dose for a desired duration with few unwanted aside effects. The time of onset and duration of effect vary depending on the method of Begin with a small dose of high CBD/low THC oil, especially if you have little or.