Testicular Steroidogenesis | SpringerLink
Testosterone may be further metabolized into a more potent androgen, dihydrotestosterone. In recent years an alternate pathway of dihydrotestosterone biosynthesis without using testosterone as a precursor has emerged. Majority of classically studied effects of androgens are thought to be mediated via nuclear receptor-dependent long-term transcriptional effects, but there also exist membrane receptor-based effects of androgens which are being uncovered from recent studies that may explain rapid effects of androgens in many cases.
In this chapter we are describing the biosynthesis, mechanism of action, and therapeutic effects of testosterone and related androgens. This work has been supported by the Swiss National Science Foundation grant Reference work entry First Online: This is a preview of subscription content, log in to check access.
Acknowledgments This work has been supported by the Swiss National Science Foundation grant The backdoor pathway to dihydrotestosterone. Of marsupials and men: The adrenogenital syndrome with deficiency of 3 beta-hydroxysteroid dehydrogenase. Bose HS, Sugawara T, et al. The pathophysiology and genetics of congenital lipoid adrenal hyperplasia.
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