The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendonWe measured the nandrolone decanoate collagen synthesis of prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase both en zymes of collagen biosynthesis and the nandrolone decanoate collagen synthesis of hydroxyproline in male rat soleus muscle and Achilles tendon during anabolic steroid treatment steroid use and pancreatic cancer 1 and 3 weeks. The rats were treated using a therapeutic dos age or a dosage that was five times the therapeutic level. After 3 weeks, the activities were at the control level. Anabolic steroid treatment seems to have at least a transitory effect on collagen biosyn thesis in male rat muscle and tendon; in tendon this effect is seen only with high doses. Karpakka, MDMaija K.
DECA-DURABOLIN Weakens Tendons and Collagen
We measured the activities of prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase both en zymes of collagen biosynthesis and the concentration of hydroxyproline in male rat soleus muscle and Achilles tendon during anabolic steroid treatment at 1 and 3 weeks.
The rats were treated using a therapeutic dos age or a dosage that was five times the therapeutic level. After 3 weeks, the activities were at the control level. Anabolic steroid treatment seems to have at least a transitory effect on collagen biosyn thesis in male rat muscle and tendon; in tendon this effect is seen only with high doses.
Karpakka, MD , Maija K. Pesola, MD , and Timo E. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click on download. Skip to main content. The American Journal of Sports Medicine. The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon.
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London, Academic Press, , pp 53 Google Scholar. Changes in body weight of normal and castrated rats by different doses of testosterone propionate. Proc Soc Exp Biol Med Kochakian CD , Robertson E. Sites and nature of protein anabolism stimulated by testosterone propionate in the rat. Am J Physiol Effects of ageing and physical training on rat skeletal muscle. An experimental study on the properties of collagen, laminen, and fibre types in muscles serving different functions.
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