About HGH: How is Human Growth Hormone Genetically Engineered?HUMAN growth hormone produced in bacteria that have been manipulated by gene-splicing techniques is expected to be tested for the first time in humans within the next several weeks, but it is unclear whether the first tests will be in Europe or the United States. Some medical scientists hope the hormone will prove valuable in a broad range of human growth hormone genetically engineered uses including healing of fractures, regrowth of tissues after severe burns, healing human growth hormone genetically engineered injured cartilage and winstrol pct needed of cases of bleeding peptic ulcers in patients who are seriously ill. It has even been considered for treating some children with juvenile rheumatoid arthritis. Because the substance is so scarce, however, it has not been possible to test any of these possibilities adequately. The only conventional source of supply is human pituitary glands obtained at autopsies.
HUMAN GROWTH HORMONE MADE BY BACTERIA: TESTS IN PATIENTS NEXT STEP IN - The New York Times
HUMAN growth hormone produced in bacteria that have been manipulated by gene-splicing techniques is expected to be tested for the first time in humans within the next several weeks, but it is unclear whether the first tests will be in Europe or the United States. Some medical scientists hope the hormone will prove valuable in a broad range of medical uses including healing of fractures, regrowth of tissues after severe burns, healing of injured cartilage and treatment of cases of bleeding peptic ulcers in patients who are seriously ill.
It has even been considered for treating some children with juvenile rheumatoid arthritis. Because the substance is so scarce, however, it has not been possible to test any of these possibilities adequately. The only conventional source of supply is human pituitary glands obtained at autopsies. Recombinant DNA technology, known popularly as gene splicing, has made it possible to modify bacteria to produce the human hormone.
This has raised hopes of virtually unlimited supplies and widespread testing in humans. The British scientific weekly Nature reported recently that human growth hormone produced by bacteria would be tried in humans soon at Great Ormond Street Hospital for Sick Children in London under sponsorship of Genentech Inc. Observers of the gene-splicing industry expect the California company to seek trials in this country promptly, but yesterday a Genentech spokesman declined to comment.
Growth hormone is the most abundant product of the body's master gland, the pituitary, which is at the base of the brain. Directly and indirectly, it has many effects on the body. But, because of its scarcity, use of the hormone has been largely limited to treating children who have serious growth deficiencies because of the failure of their own growth hormone.
He said it took all of the growth hormone from 50 human pituitary glands to treat one growth-deficient child for a year. To achieve useful results, the treatment usually has to be substantially longer. Baxter's team and a group of scientists at Genentech succeeded almost simultaneously in in producing human growth hormone in genetically modified bacteria.
The first tests in humans are expected to begin less than two years after that research accomplishment. Like many other accomplishments of gene-splicing, this one has proceeded far faster than many had expected.
Last year, when the possibility of medical use of hormones produced in bacteria was becoming apparent, the Food and Drug Administration called a special meeting of one of its advisory committees to discuss the potential risks and benefits of such products as human growth hormone, insulin and interferon, the antivirus substance.
View all New York Times newsletters. At that meeting Dr. Daniel Rudman of Emory University said the many known direct and indirect effects of human growth hormone under natural circumstances suggest the possibility of many medical uses, prompting research at several institutions. Human growth hormone stimulates the production of protein in cells of most types, he said; accelerates the production of the two master chemicals of heredity, DNA deoxyribonucleic acid and RNA ribonucleic acid ; stimulates the manufacture of red blood cells and augments the flow of blood to the kidneys and the rate at which the kidney does its vital filtration work.
Decreases Stores of Fat. The hormone seems to decrease the body's stores of fat and increase muscle mass and the tissues of liver, kidney and heart. The best known action is in stimulating bone growth and skeletal development, the effect that makes it valuable in correcting serious growth problems in some children.
In a study of experimental wound healing in rats, one group of scientists found growth hormone effective in aiding the late stages of recovery from burns, Dr. Rudman said in his review of research. A study of growth hormone in severe burn patients showed less success, he said, but suggested that the treatment might be useful, provided doses could be given that were far larger than those used to treat pituitary growth deficiency. Severe bleeding peptic ulcers that sometimes afflict patients seriously ill with diseases such as cancer, also seem a likely target for growth hormone.
In one study, six of eight seriously ill cancer patients given the treatment survived a serious ulcer bleeding episode while only two of eight not given the treatment survived. The useful effect was attributed to stimulation of production of collagen fibrils to help blood clotting.
Medical scientists have found some evidence that the hormone might be useful in helping reunite difficult fractures, but have reported generally disappointing results in using the substance to combat the bone weakening of osteoporosis in the elderly. The first bacterially produced human hormone to be tested in humans for medical purposes was human insulin manufactured in bacteria by the Eli Lilly Company.
This insulin is now undergoing major testing in diabetics in the United States after tests in England demonstrated that it was effective and that its use apparently involved no special hazards. The insulin-producing recombinant bacteria were also developed by Genentech. Please upgrade your browser. View page in TimesMachine. Newsletter Sign Up Continue reading the main story Please verify you're not a robot by clicking the box. You must select a newsletter to subscribe to.
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