EliteFitness.com Bodybuilding ForumsPage 1 of 2 1 2 Last Jump to page: Results 1 to 15 of I got some proviron cause I read it is a good addition to a PCT. Monday was my final injection and in two weeks I will start taking anavar (oxandrolone) preco of hcg a week for proviron tamoxifen pct weeks along with 40mg nolvadex. I am going to continue the novladex for 2 additional weeks.
proviron and PCT
Page 1 of 2 1 2 Last Jump to page: Results 1 to 15 of I got some proviron cause I read it is a good addition to a PCT. Monday was my final injection and in two weeks I will start taking iu of hcg a week for 2 weeks along with 40mg nolvadex. I am going to continue the novladex for 2 additional weeks.
Any suggestions on how to mix the proviron in? I figured 50mg a day but should I start now or wait till I start the rest? I've never used it in my life and dont see a reason to. Proviron Mesterolone Proviron is an anabolic steroid with little direct anabolic properties.
It has good binding qualities with the androgen receptor, but most never reaches the androgen receptor in muscle tissue, as it is enzymatically converted to diol. It is however effective as an anti-aromatase, and is believed to also act in an anti-oestrogenic manner due to certain oestrogen receptor down-regulation, making it a very effective compound for preventing gyno.
Proviron also helps restore sexual dysfunctions caused by steroid cycling, helping to increase sexual desire as a result of the increased androgen levels, a downside can be permanent erections in some males which at first may sound fantastic but can be extremely painful, in which case the dose should be lowered or discontinued. Proviron will also help reduce excess bloating caused by water retention.
Proviron can be used effectively throughout clomid therapy as it displays no signs of inhibiting the HPTA see article 'Clomid and HCG' , and is helpful in keeping androgen levels elevated until natural testosterone production is restored correctly.
The androgenic activity is also responsible for the distinct hardening of muscles and is one reason it is often favoured leading up to competitions. Dosing Proviron is supplied in 25mg tablets. Dose is best split am and pm. I disagree with that article. I definately feel proviron shuts you down. Ran it by itself pre-contest as a hardener, and it still shuts you down. Drug profile from Big Cat M esterolone is an orally active, 1-methylated DHT. Like Masteron, but then actually delivered in an oral fashion.
DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. One would imagine then that mesterolone would be a perfect drug to enhance strength and add small but completely lean gains to the frame. Unfortunately there is a control mechanism for DHT in the human body.
When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha 5-alpha-androstan-3alpha,17beta-diol , a prohormone if you will.
But it means that unless one uses ridiculously high amounts, most of what is administered is quite useless at the height of the androgen receptor in muscle tissue and thus mesterolone is not particularly suited, if at all, to promote muscle hypertrophy. P roviron has four distinct uses in the world of bodybuilding.
The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme which converts testosterone to estrogen than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen.
So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains.
Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels. T he second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin SHBG and albumin, two proteins.
In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.
T hirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing "harder" muscles with more cuts and striations.
Proviron is often used as a last-minute secret by a lot of bodybuilders and both actors and models have used it time and again to deliver top shape day in day out, when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat. L astly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don't have the same affinities as DHT does.
Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect.
Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favorite in medical practices due to its lower chance of abuse.
M esterolone is generally well liked nonetheless as it delivers very few side-effects in men. In high doses it can cause some virilization symptoms in women. But because of the high level of deactivation and pre-destination in the system albumin, SHBG, 3bHSD, aromatase quite a lot of it, if not all simply never reaches the androgen receptor where it would cause anabolic effects, but also side-effects.
So its relatively safe. Doses between 25 and mg per day are used with no adverse effects. Unlike what some suggest or believe, its not advised that Proviron be used when not used in conjunction with another steroid, as it too is quite suppressive of natural testosterone, leading to all sorts of future complications upon discontinuation.
Ranging from loss of libido or erectile dysfunction all the way up to infertility. One would not be aware of such dangers because Proviron fulfills most of the functions of normal levels of testosterone. M esterolone is an oral alkylated steroid. If used primarily as an anti-aromatase drug, using it throughout a longer cycle weeks of injectables may elevate liver values a little bit, though much, much less than one would expect with a alpha-alkylated steroid. Eventhough instead of inhibiting gains, mesterolone may actually contribute to gains.
So that's a bit of a shame. Its not quite as toxic since its not alkylated in the same fashion, but at the 1 position, which reduces hepatic breakdown, but not like alpha alkylation.
The reason for the change of position I assume, is because alkylating at the alpha position has been shown to reduce affinity for sex hormone binding proteins. This would in turn decrease its ability to free testosterone.
Nonetheless the delivery rate is quite good. Its taken daily in mg doses. T he best thing to stack it with is testosterone of course. Since the DHT can compete for these structures with higher affinity it would naturally lead to a higher yield of whatever testosterone product you stacked it with. Since DHT levels are notably higher now there is also more stimulation of the androgen receptor causing more strength gains, and because of its affinity for aromatase the overall estrogen level decreases as well.
This has as a result that gains are leaner, and once again the overall testosterone yield is increased as less I converted at the aromatase enzyme. I t's of course used in other stacks with products such as methandrostenolone, boldenone and nandrolone to reduce estrogenic activity and increase muscle hardness.
The addition of proviron makes boldenone a dead lock for a cutting stack and for some may even make it possible to use nandrolone while cutting, although the use of Winstrol or a receptor antagonist in conjunction is wishful as well.
The benefit of adding it to a nandrolone stack is that it may also help you reduce the decrease in libido suffered from nandrolone, since the latter is mostly deactivated by 5-alpha reductase, an enzyme that makes other hormones more androgenic.
P roviron is an anti-aromatase, so obviously anti-estrogens would be futile and redundant. Blood pressure medication for those prone to hypertension may be wise, as this DHT can increase the blood pressure. No High Blood Pressure: Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level.
It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously.
In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an anti-estrogen.
It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex though less profound , the drug acting to prevent the buildup of estrogen in the body.
This is in direct contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action.
This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles.
With each item attacking estrogen at a different angle, side effects are often greatly reduced. The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron 2methyl-dihydrotestosterone for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect.
It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion the most active site of nandrolone aromatization seems to be the liver.